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AKT activation because of PTEN loss upregulates xCT via GSK3β/NRF2, leading to inhibition of ferroptosis in PTEN-mutant tumor cells - ScienceDirect

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Further investigation identified a negative correlation between p53 activation and the promotion of p21 Waf1/CIP1 expression, which enhances apoptosis in gambogic acid-treated MCF-7 cells via suppression of MDM2 (Rong et al., 2009[189])

cure or prevent any disease.